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What is Esketamine?


Esketamine nasal spray is a medication used for the treatment of depression in adults who have not responded to other treatments. It is a type of anesthesia that works by affecting certain chemicals in the brain. It is only available with a prescription and should only be used under the supervision of a healthcare professional.

Why Esketamine?

If you’ve taken two or more oral antidepressants and still experience symptoms of depression, you might have treatment-resistant depression(TRD). It might be time to talk to your doctor about a different treatment approach. See what makes SPRAVATO® different and learn more about other patients’ experiences with SPRAVATO®.

How will I take SPRAVATO®?

  • You will take SPRAVATO® nasal spray yourself, under the supervision of a healthcare provider in a healthcare setting. Your healthcare provider will show you how to use the SPRAVATO® nasal spray device.

  • Your healthcare provider will tell you how much SPRAVATO® you will take and when you will take it.

  • Follow your SPRAVATO® treatment schedule exactly as your healthcare provider tells you to.

  • During and after each use of the SPRAVATO® nasal spray device, you will be checked by a healthcare provider who will decide when you are ready to leave the healthcare setting.

  • You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO®.

  • If you miss a SPRAVATO® treatment, your healthcare provider may change your dose and treatment schedule.

  • Some people taking SPRAVATO® get nausea and vomiting. You should not eat for at least 2 hours before taking SPRAVATO® and not drink liquids at least 30 minutes before taking SPRAVATO®.

  • If you take a nasal corticosteroid or nasal decongestant medicine take these medicines at least 1 hour before taking SPRAVATO®.

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